told me not to tell anyone," he told the AP, adding that he just sat in his office, shaking a bit. Meldal said he received the call from the Nobel panel about half an hour before the public announcement. One of three daughters, Bertozzi said she was "fortunate because I grew up with parents that were very supportive, evangelical almost, about having their girls participate in the sciences."īertozzi, who is paid by the Howard Hughes Medical Institute, which also supports The Associated Press' Health and Science Department, said she was grateful for the energy and enthusiasm that a Nobel Prize win will inject into the field. After she assured him nothing was wrong, he guessed the news. "Dad, turn down the TV, I have something to tell you," she said she told him. was her father, William Bertozzi, a retired physicist and night owl, who was still awake watching TV. Later, speaking to The Associated Press by Zoom, Bertozzi said one of the first people she called after being awakened by the call around 2 a.m. "I'm still not entirely positive that it's real, but it's getting realer by the minute." The goal is "doing chemistry inside human patients to make sure that drugs go to the right place and stay away from the wrong place," she said at a news conference following the announcement. Meldal, 68, based at the University of Copenhagen, and Sharpless, who is affiliated with Scripps Research in California, independently found the first such candidates that would easily snap together with each other but not with other molecules, leading to applications in the manufacture of medicines and polymers.īertozzi, 55, who is based at Stanford University "took click chemistry to a new level," the Nobel panel said, by finding a way to make the process work inside living organisms without disrupting them. "They have to react with each other easily and specifically." "The problem was to find good chemical buckles," he said. Sharpless, 81, who previously won a Nobel in 2001 and is now the fifth person to receive the prize twice, first proposed the idea of connecting molecules using chemical "buckles" around the turn of the millennium, Aqvist said. "It's all about snapping molecules together," said Johan Aqvist, a member of the Royal Swedish Academy of Sciences that announced the winners at the Karolinska Institute in Stockholm. Barry Sharpless, and Danish scientist Morten Meldal were cited for their work on click chemistry that works "sort of like molecular Lego." Three scientists were jointly awarded this year's Nobel Prize in chemistry on Wednesday for developing a way of "snapping molecules together" that can be used to explore cells, map DNA and design drugs that can target diseases such as cancer more precisely.Īmericans Carolyn R.
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